letrozole is that working and when i should take it !Letrozole Femara and Arimidex lettrozole the two most popular aromatase inhibitors of the 3 major AIs, with Letrozole being the second most popular. Letrozole has demonstrated some very incredible efficiency in the reduction letrozole dbol test Estrogen, more so than the other two major natural t boosters inhibitors. In comparison with the Arimidex, Letrozole has been found to be 10 — 20 times the strength of Arimidex, and although Letrozole doses are equally as effective as Aromasin, it operates through a different pathway buy winstrol mexico order to be highly effective in its own right . However, the context that an anabolic steroid using athlete or bodybuilder is slightly different from the medical and clinical letrozole dbol test of Letrozole or any aromatase inhibitor, and this is what any anabolic steroid user is most concerned with: It must first be understood that Letrozole is an aromatase inhibitor, with a wide dbo, of application letrozole dbol test terms of Estrogen control.
dbol & letrozole??
Letrozole Femara and Arimidex are the two most popular aromatase inhibitors of the 3 major AIs, with Letrozole being the second most popular.
Letrozole has demonstrated some very incredible efficiency in the reduction of Estrogen, more so than the other two major aromatase inhibitors. In comparison with the Arimidex, Letrozole has been found to be 10 — 20 times the strength of Arimidex, and although Letrozole doses are equally as effective as Aromasin, it operates through a different pathway in order to be highly effective in its own right . However, the context that an anabolic steroid using athlete or bodybuilder is slightly different from the medical and clinical application of Letrozole or any aromatase inhibitor, and this is what any anabolic steroid user is most concerned with: It must first be understood that Letrozole is an aromatase inhibitor, with a wide variety of application in terms of Estrogen control.
As an aromatase inhibitor, it holds the ability to exert control over literally all of the potential Estrogenic side effects that anabolic steroid users attempt to avoid or eliminate. The standard protocol or general rule for the use of all aromatase inhibitors should be the following:. Attempt to avoid the use of aromatase inhibitors at all costs unless absolutely necessary.
If the use of an aromatase inhibitor is necessary, utilize it only when required, and attempt the lowest possible dose for the purpose of Estrogen control rather than Estrogen elimination. This is extremely important and must be remembered by all readers investigating the use of aromatase inhibitors. The fact of the matter is that the use of aromatase inhibitors, whether it be the three primary AIs Arimidex, Aromasin , and Letrozole or any others, will exert negative effects on the body if utilized when they are either unneeded, or when they are utilized too much at Letrozole doses that are too high.
Remember that the reason for the use of an aromatase inhibitor should at all times be for the purpose of Estrgen control rather than Estrogen elimination , as the complete and total reduction of all Estrogen levels in the body can and does result in deleterious effects on the human body.
This will be further explained in the side effects portion of this profile, but a general description is that these compounds aromatase inhibitors deprive the body of a very important hormone Estrogen that is important for various essential bodily functions at normal physiological levels.
Letro is approved by the FDA for the treatment of post-menopausal female breast cancer patients as an adjunctive treatment when first-line treatments such as Nolvadex have failed to work. It is also approved for the extended treatment for post-menopausal female breast cancer patients after 5 years of Nolvadex administration.
This is a breast cancer condition in which the diagnosis indicates that it is unknown as to whether or not Estrogen is the culprit, or whether or not the breast cancer is aggravated by Estrogen. Finally, it is also approved for the treatment of post-menopausal female breast cancer patients for whom all other anti-Estrogen compounds have not worked this includes SERMs and all other AIs. Letrozole is often the last-resort and final treatment attempt for breast cancer patients when all else has failed.
Letrozole in particular cannot be categorized into the three tiers of users beginner, intermediate, and advanced as normally outlined and listed in common profiles of the different compounds and drugs. In some instances, Letrozole doses might possibly also be utilized to increase the endogenous secretion of Testosterone in men, which allows this compound to be utilized as an ancillary medication during PCT Post Cycle Therapy phases following the end of an anabolic steroid cycle, but its use on its own for this purpose is not very common and is unlikely to produce noticeable performance enhancing effects.
For the purpose of Estrogen control during a cycle: Letrozole is the most effective aromatase inhibitor utilized to reduce levels of circulating Estrogen in the body during a cycle involving the use of aromatizable androgens anabolic steroids that have an affinity to bind to the aromatase enzyme and undergo aromatization into Estrogen. This has been outlined previously in the introduction. With this being said, the general range of Letrozole dose s are approximately 1.
There does exist a very large margin for adjustment and user preference when it comes to Letrozole dosages, as each individual should slowly adjust their dose depending on how they feel the body is responding. This is especially so for Letrozole, which is the most powerful and potent AI of the three. These Letrozole doses can easily be adjusted if the user feels it is not working well enough, or if it is reducing Estrogen levels too much.
It has been a proven fact both in clinical data involving mice, as well as anecdotal evidence that Letrozole is indeed capable of reversing and eliminating gynecomastia progression. This is one particular effect that is slightly more unique to Letrozole itself.
It should be known that other aromatase inhibitors can exhibit this effect as well, but if gynecomastia has progressed beyond a certain point, it will be irreversible and removal must be done through surgery. One particular study on mice demonstrated that receptor overexpression caused by Estrogen that induced mammary gland changes were destroyed with even low doses of Letrozole .
Although these studies were performed on mice, there are plenty of anecdotal reports of bodybuilders developing gynecomastia who have utilized Letrozole in combination with a SERM such as Nolvadex that have effectively reduced and eliminated progressing gynecomastia where all other treatment attempts have failed. Although gynecomastia reversal is not guaranteed especially depending on circumstances , it is worth a try for individuals who especially have recently developed gynecomastia the sooner the treatment following gynecomastia development, the better.
Female anabolic steroid users seldom need to worry about rising Estrogen levels , but for those that are competitive bodybuilders that must eliminate the water retention associated with Estrogen that causes the unwanted bloating, the use of an aromatase inhibitor such as Letrozole Femara might be necessary.
However, because of the immense strength of Letrozole, it is recommended that females attempt the use of one of the other two major aromatase inhibitors prior to resorting to Letrozole use. This is because it has been demonstrated medically that aromatase inhibitors in fact do impact Estrogen reduction in females far greater than that of males.
It is important to remember that medically, Letrozole is approved for use in post-menopausal females only, who possess a very different shift in hormone levels compared to pre-menopausal females.
Even among post-menopausal female breast cancer patients, Letrozole is utilized as the absolute last resort last-line of defense against breast cancers after all other treatments and drugs have failed.
Because medical data has suggested that aromatase inhibitors are far more effective in females than males depending on the aromatase inhibitor in question used , Letrozole doses of 1. It has been previously mentioned that Letrozole holds the potential to raise the endogenous production of Testosterone levels in men. This is through the negative feedback loop of the HPTA Hypothalamic Pituitary Testicular Axis , whereby it has been found that excess Estrogen in men can and does suppress the output of endogenous Testosterone, leading to hypogonadism .
Letrozole in particular in many studies has demonstrated to hold the capability to raise Testosterone levels through the reduction of Estrogen. One particular study evaluated an elderly male exhibiting sexual dysfunction issues resultant of low endogenous androgen production that was administrated with Letrozole doses, and the study concluded that Testosterone levels were restored normal physiological levels and sexual function was restored .
LH and FSH are the two important gonadotropins that signal the testes to begin production of Testosterone , while SHBG is a protein that binds to androgens and renders them inactive in much the same way aromatase inhibitors will bind to the aromatase enzyme and render it inactive. One can easily conclude, based on the data provided, that Letrozole would be an effective addition to the necessary increases in Testosterone required during the post-cycle weeks following cessation of anabolic steroid use.
This same problem is evident in Arimidex, but not in Aromasin Exemestane. The problem is that Letrozole and Nolvadex as well as Arimidex and Nolvadex both directly counteract one another. One study has demonstrated that when Letrozole is utilized with Nolvadex, Nolvadex will decrease blood plasma concentration of Letrozole as well as Arimidex, another commonly used aromatase inhibitor . The conclusion here is that the use of Letrozole and Nolvadex together is a very bad idea.
Instead, its use with HCG might be more beneficial, but this also presents the problem of the essential component of a SERM for the purpose of endogenous Testosterone stimulation being absent.
Therefore, a better aromatase inhibitor choice for PCT instead of Arimidex would be Aromasin Exemestane , because unlike Letrozole, Aromasin has it has not been demonstrated have its effectiveness eliminated or reduced by Nolvadex as shown in studies . There are no special considerations with administration of Letrozole doses, and it can be taken at any time of the day morning, night time, before, during, or after meals. One important note to make with Letrozole doses is that it in fact takes 60 days before blood plasma levels of Letrozole have reached its optimal peak level, even though its half-life is approximately 2 — 4 days .
Because Letrozole is by far the most effective aromatase inhibitor with the ability to reduce Estrogen levels to undetectable levels, users must be cautious to ensure that these Estrogen levels do not plummet too low to be considered healthy.
This results in very little to no subcutaneous fluid, which will present the underlying musculature more prominently. The one exception to the issue of complete Estrogen elimination is in competitive bodybuilders that require almost total elimination of water retention on the competition day.
Near-total reduction of Estrogen should not be maintained for more than a 48 hour period for health reasons. J Steroid Biochem Mol Biol. Life Extension Magazine, November Boeddinghaus IM, Dowsett M. Dan's educational emphasis is on performance enhancement drugs PEDs , endocrinology, nutritional supplements and strategies for health, fat reduction, anti-ageing, muscle growth, disease control and vaccinations.
Dan has had an interest in learning and writing about steroid use for over 15 years. The standard protocol or general rule for the use of all aromatase inhibitors should be the following: Medical Letrozole Dosage Letro is approved by the FDA for the treatment of post-menopausal female breast cancer patients as an adjunctive treatment when first-line treatments such as Nolvadex have failed to work.
Letrozole Dosage During Anabolic Steroid Use Letrozole in particular cannot be categorized into the three tiers of users beginner, intermediate, and advanced as normally outlined and listed in common profiles of the different compounds and drugs.