Page not availableThe somatic cells of a multicellular organism contain an identical complement of genes that need to be expressed specifically human growth hormone gene family appropriately to allow the normal development and gsne associated with an organism. In the eukaryotic cell nucleus, genes are packaged with nucleoprotein histones into chromatin. Appropriate expression in vivo is dependent on remote sequences found kb upstream of GH-N in the loci of adjacent genes, and these sequences are characterized by five I-V nuclease-hypersensitive sites HS. Positively or negatively growfh those components known to be important for pituitary transcription may link epigenetic events to key transcription factors in the overall picture of tissue-specific control of gene expression. National Center for Biotechnology InformationU.
The Human Growth-Hormone Gene Family | SpringerLink
Gelinas; The human growth hormone gene family: The structure of the human growth hormone gene cluster has been determined over a 78 kilobase region of DNA by the study of two overlapping cosmids. There are two growth hormone genes interspersed with three chorionic somatomammotropin genes, all in the same transcriptional orientation. One of the growth hormone genes lies in an active chromatin conformation in the pituitary and at least one of the chorionic somatomammotropin genes lies in an active chromatin conformation in the placenta.
Analysis of the sequences of the genes and identification of at least three different classes of duplication units interspersed throughout the five gene cluster suggests that the cluster evolved quite recently and that the mechanism of gene duplication involved homologous but unequal exchange between middle repetitive elements of the Alu family. Oxford University Press is a department of the University of Oxford.
It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Close mobile search navigation Article navigation. The human growth hormone gene family: Abstract The structure of the human growth hormone gene cluster has been determined over a 78 kilobase region of DNA by the study of two overlapping cosmids.
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