Depo-Medrol DosageNot for epidural use; serious neurologic events medrol dose injection occur. Cerebral malaria, optic neuritis: Latent or tren x1x amebiasis. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending.
DEPO-MEDROL (Methylprednisolone) dosage, indication, interactions, side effects | EMPR
Not for epidural use; serious neurologic events may occur. Cerebral malaria, optic neuritis: Latent or active amebiasis. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Supplement with additional steroids in physiologic stress.
May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8 AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Potentiated by CYP3A4 inhibitors eg, ketoconazole, macrolides , cyclosporine, estrogens. Antagonized by CYP3A4 inducers eg, barbiturates, phenytoin, carbamazepine, rifampin , cholestyramine.
May potentiate cyclosporine seizure risk. May antagonize oral anticoagulants monitor , isoniazid. Increased risk of arrhythmias with digitalis. May need to adjust dose of antidiabetic agents. Monitor for hypokalemia with potassium-depleting drugs eg, amphotericin B, diuretics. Concomitant neuromuscular blocking agents; increased risk of myopathy. Withdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapy.
Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression. Caution with aspirin in hypoprothrombinemia. May suppress reactions to skin tests. HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance. Tabs, dosepak YES ; Depo-medrol: Generic Name and Formulations: Steroid-responsive disorders when oral therapy not feasible.