TranscortinThe steroid binding domain of the rat glucocorticoid receptor is considered as extending from amino acids to However, such a synthetic protein i. This kDa fragment retains high affinity binding for [3H]dexamethasone that is only approximately fold lower than that seen with the intact kDa receptor. Analysis of the protease digestion patterns bindiing both with trypsin and with lysylendopeptidase C allowed us to deduce steroid binding activity proteolytic cleavage maps of the receptor with these enzymes. Steroid binding activity these protease maps, the sequence of the kDa fragment was identified as being threonine to arginine
Glucocorticoid receptor thiols and steroid-binding activity. - PubMed - NCBI
It is an alpha-globulin. This gene encodes an alpha-globulin protein with corticosteroid -binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates.
The gene localizes to a chromosomal region containing several closely related serine protease inhibitors serpins which have evolved by duplication events. Transcortin is produced by the liver and is increased by estrogens.
Mutations in this gene are rare. Only four mutations have been described, often in association with fatigue and chronic pain. This condition must be distinguished from secondary hypocortisolism. Exogenous hydrocortisone does not appear to improve the fatigue.
Hepatic synthesis of corticosteroid-binding globulin more than doubles in pregnancy; that is, unbound plasma cortisol in term pregnancy is approximately 2. From Wikipedia, the free encyclopedia. Chromosome 14 human . Am J Hum Genet. Edward Bittar; Neville Bittar Molecular and Cellular Endocrinology. Retrieved 23 August The Journal of Clinical Endocrinology and Metabolism.
Shnider and Levinson's anesthesia for obstetrics. Maruyama K, Sugano S Differential processing and significance of carbohydrate chains at individual sites". Retinol binding protein 1 2 3 4 Transcobalamin. Sex hormone-binding globulin Transferrin. Beta-lactoglobulin Lactoferrin Thyroglobulin Alpha-lactalbumin 11S globulin family seeds 7S globulin family seeds. Human serum albumin Bovine serum albumin Prealbumin. C-reactive protein Lactalbumin Alpha-lactalbumin Parvalbumin Ricin.
Available structures PDB Ortholog search: Chromosome 12 mouse . More reference expression data. Egg white Conalbumin Ovalbumin Avidin. Agonists Cortisol-like and related unsubstituted: