Sustanon 250, 250mg/ml solution for injectionSustanon usp contains 4 testosterones that due to different time release provide steady and even testosterone displacement over a period of 4 -6 weeks. Hate paying too sustanln Our prices are reasonable. Where to buy inexpensive sustanon testosterone? Fast, cheap, right on sustanon usp money.
Sustanon description or profile | sustanon
Sustanon contains 4 testosterones that due to different time release provide steady and even testosterone displacement over a period of 4 -6 weeks. Hate paying too much? Our prices are reasonable. Where to buy inexpensive sustanon testosterone?
Fast, cheap, right on the money. Sustanon contains 4 different testorones one of them is: Testosterone cypionate injection, USP, for intramuscular injection, contains Testosterone cypionate which is the oil-soluble 17 beta -cyclopentylpropionate ester of the androgenic hormone Testosterone. Testosterone cypionate is a white or creamy white crystalline powder, odorless or nearly so and stable in air.
It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils. Its molecular formula is C27H40O3, and the molecular weight Testosterone cypionate mg Benzyl benzoate 0.
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution.
Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process.
Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor. During exogenous administration of androgens, endogenous Testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone LH. At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone FSH. There is a lack of substantial evidence that androgens are effective in fractures, surgery, convalescence, and functional uterine bleeding.
Testosterone esters are less polar than free Testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone cypionate can be given at intervals of two to four weeks. Testosterone in plasma is 98 percent bound to a specific Testosterone-estradiol binding globulin, and about 2 percent is free.
Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of Testosterone between free and bound forms, and the free Testosterone concentration will determine its half-life.
About 90 percent of a dose of Testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of Testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the conjugated form. Inactivation of Testosterone occurs primarily in the liver. Testosterone is metabolized to various keto steroids through two different pathways.
The half-life of Testosterone cypionate when injected intramuscularly is approximately eight days. In many tissues the activity of Testosterone appears to depend on reduction to dihydroTestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Sustanon injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous Testosterone. Primary hypogonadism congenital or acquired testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy. Hypogonadotropic hypogonadism congenital or acquired idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.
Known hypersensitivity to the drug 2. Males with carcinoma of the breast 3. Males with known or suspected carcinoma of the prostate gland 4.
Women who are or who may become pregnant 5. Patients with serious cardiac, hepatic or renal disease. Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued. Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking. Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease.
This product contains benzyl alcohol. Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height.
This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose. Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage.
If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized. Testosterone cypionate should not be used interchangeably with Testosterone propionate because of differences in duration of action. Patients should be instructed to report any of the following: Hemoglobin and hematocrit levels to detect polycythemia should be checked periodically in patients receiving long-term androgen administration. Androgens may increase sensitivity to oral anticoagulants.
Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia. Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. Testosterone has been tested by subcutaneous injection and implantation in mice and rats.
The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of Testosterone into some strains of female mice increases their susceptibility to hepatoma.
Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats. There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases.
Safety and effectiveness in pediatric patients below the age of 12 years have not been established. The following adverse reactions in the male have occurred with some androgens: Gynecomastia and excessive frequency and duration of penile erections.
Oligospermia may occur at high dosages. Hirsutism, male pattern of baldness, seborrhea, and acne. Fluid and Electrolyte Disturbances. Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates. Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia. There have been no reports of acute overdosage with the androgens.
Testosterone Dosage and Administration. It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle. The suggested dosage for Sustanon injection, USP varies depending on the age, sex, and diagnosis of the individual patient. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels.
Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. For replacement in the hypogonadal male, 50 to mg should be administered every two to four weeks. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended. How is Testosterone Supplied. Testosterone cypionate Dosage Form: The structural formula is represented below: Pharmacokinetics Testosterone esters are less polar than free Testosterone.
Indications and Usage for Sustanon Sustanon injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous Testosterone. Patients with serious cardiac, hepatic or renal disease Warnings Hypercalcemia may occur in immobilized patients.
Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism. Precautions General Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Testosterone cypionate is not for intravenous use.