Curcumin of the Increasing Bioavailability

galitun5
19.06.2018

Content:

  • Curcumin of the Increasing Bioavailability
  • Why Pepper Boosts Turmeric Blood Levels
  • 94 comments on “Curcumin Will Waste Your Time”
  • To increase the bioavailability of curcumin different formulations have been made . Among them, nanoglobules based. How do you increase the bioavailability of curcumin naturally into your body? We have taken a closer look at it and here are a few simple ways. The prospect of improving the bioavailability of curcumin and the subsequent enhancement of its bioactivity could monumentally alter the.

    Curcumin of the Increasing Bioavailability

    Any thoughts on lessening the oxidation effect when blending? Hi really great info thank you i just wondered as there is conflicting information what is better — the powder or cold pressed juice from the root?

    If taken with black pepper, an oil and acv. There has been no study as such comparing the turmeric powder and turmeric juice. However we would recommend the powder with black pepper, oil and ACV for health benefits. You can consume the juice occasionally; that is awesome for health as well. But for therapeutic benefits we would suggest using powder. I would like to ask what is the best way to treat acne using turmeric?

    How should it be applied? Should it still be mixed with oil virgin coconut oil? This depends on your skin type. Mixing turmeric with coconut oil and using it as a spot treatment is a good option. You can apply it times in day but please conduct a patch test prior. Please check this article: Thank you for this very informative article. I blend turmeric with stabilized ground flaxseed and freshly ground black peppercorns to feed to my horses. Is the fat in the ground flaxseed sufficient to aid in absorption?

    Flaxseed should serve as a good source of fats and flaxseed meal should be sufficient for absorption of turmeric. I want to know if Termaric and black pepper when mixed with honey are good in regards to absorbtion and bioavailability. Black pepper aids in absorption of turmeric. It is safe to mix the two with honey. However please take care about the amount of sugar in any form you consume throughout the day. You can use freshly ground organic black pepper.

    I am using it with one spoon of olive oil and some drops of Apple cider vinegar. I am suffering from minimal change disease for over 10 years. The animal fats is the culprits in my case.

    Presently, I have tried curcumin with black papers and my immune system reacted in the same way as eating meat, fish and chicken and made me unwell.

    My request to you is what could be the common in this case. Thank you and regards,. You can find the dosage of turmeric and curcumin for cancer here: I have purchased organic turmeric powder and organic black peppercorns that I grind with a coffee grinder. I am in the process or ordering Quercetin in some form to either add to this or take along with. At what ratio should I mix these, so that I can fill my own capsules. Right now we are taking 4 daily, 2 in the morning and 2 in the evening and trying to remember to take them with a meal or some oil, such as flax seed oil.

    A co-worker recently told me that if I am not taking Bioperine with my turmeric I am just wasting the turmeric. However after reading this article and most of the comments, I think that may not be the case here. I use turmeric in my morning smoothies that also contain fresh pineapple, ground Chia seeds, ground flax seeds, occasionally black pepper, and recently coconut oil.

    It seems to me that those ingredients work well together to improve the bio availability of the turmeric. Yes absolutely, dietary turmeric gets absorbed with the food ingested as well as with the components you mentioned like black pepper, coconut oil and fat content of flax and chia seeds.

    I currently make liposomal C and want to liposome turmeric. Will I need to dissolve the turmeric in oil first or will it be okay in water? Hi…I make my own liposomal C and are wanting to now liposome turmeric. Do I need to disolve turmeric in oil first or will water do as it will in turn be liposomed inside the fat of the lecithin? I have cyst on tonsil. Can I pierce a capsule of Solgar full spectrum mg curcumin and mix with slippery elm and sip this.

    My thoughts are the slippery elm coats and remains around the area. Any thoughts or advice appreciated. We dont recommend this. You can gargle with fresh turmeric boiled in water and cooled to a lukewarm stage to prior to gargling. You could also take golden paste with honey so that it coats your throat and relieves the inflammation.

    Taking golden paste orally may help alter internal factors that would heal the cyst. You can take Golden Paste. Avoid taking it at the same time when you take other meds.

    I add tumeric to green smoothies i the morning with helmp oil plus heaps of oher goodies. I am hoping to cure glaucoma?? Any suggestions from anyone? Turmeric does help as an antioxidant in glaucoma. It is great to include turmeric in diet for better absorption. You can also try Golden Paste. There has not been any study as such with regards to this but it should help. However taking turmeric supplements after a meal should also since dietary fat would help in absorption.

    Also you could consider sprinkling some black pepper powder in your meal prior to taking turmeric supplement. Can you give any advice on making a paste out of the Tumeric to use on skin conditions like Psoriasis? Leave it for 30 mins to 1 hour or till it dries and then wash with water. Repeat this times a day. Also conduct a patch test prior. Hi Deb I used to get coldsores herpes simplex on my lip and spent a fortune on chemist medicine but since I have been using turmeric paste over one year I have not had an outbreak.

    The point I want to make is this some people are put off using turmeric paste because it stains clothes and bed cloths. Turmeric is a very transient dye washing and hanging stained clothes in the sun will quickly fade the stains and restore your clothes. So get turmeric stained clothes out into the sun. Here is a recipe combining these two: I would like to infuse some coconut oil with turmeric and black pepper to put into capsules.

    Has anyone tried this method? It would definitely help in absorption of turmeric but the capsule could melt when trying to store this mixture in it. HI Margret the capsules that I find are easily available from my chemist are not soluble in oil, they are soluble in water, so you can easily put your oil turmeric brew into them.

    We would need to research further before commenting on combining turmeric and pineapple in diet for better absorption. But tumeric lattes have what you need. Just near boil milk, coconut oil, cinnamon, tumeric, ginger, honey and pepper. I buy a large bottle of low sodium V8 juice, measure out 26 grams of turmeric, and add about teaspoons of pepper.

    A guy posted earlier, which I think is a great idea, and that is to heat some rapeseed or coconut oil I prefer up with your turmeric and black pepper and make some french toast or eggs. A lovely breakfast and massively increased bioavailability of the curcumin.

    Stick to whole milk, cream, or plain whole milk yogurt if possible. Milk alternatives might be OK for drinking cold, or enjoying with cold cereal… But, are not the best to make a nutrient bio-available —.

    I would stick as close to nature as possible. I make sure I turn pan from side to side a few times to keep distribute the heavier powders back into the blend. Do not use instant oatmeal— if you are aiming for ANY health benefits—. Initially I added it to my juicing routine then adding a little pepper. These days I eat it like a carrot. Added bonus is that it makes your teeth whiter.

    So now to be safe I just use fresh coarse pepper. To your health everyone! It is unusual to meet people so hard core and willing to chew on roots! Especially ones that are strong tasting like Turmeric. Love hearing that, and interesting. Thanks for stretching my vision of what is possible. I live in Asia and find the fresh root from the market quite sweet and OK to munch on also very cheap. It numbs the tonge for a while and makes it go yellow. Remember to brush your teeth before you leave the house.

    The turmeric in Vietnam is of good quality, very cheap and readily available.. I add some fresh turmeric, whole peppercorns, fresh basil, and whatever else I feel like to a bottle of olive oil infuse for a week or so and use it as you wish for cooking, salads, etc… The flavour is delightful for all forms of cooking..

    Is the pepper and oil necessary when eating raw? I have been eating it raw alone as I thought the pepper and oil was not necessary. The taste is awful, so I would hate to be doing this with no benefits!!! No pepper and oil are not necessary when eating raw turmeric. Turmeric has natural oils that enhance the absorption. You can check these recipes: It does have pepper and oil for additional health benefits.

    You can also check some ways to make it more palatable https: I take 3 teaspoons of turmeric each day just in plain water and it helps with oa pain. If you are not facing any side effects, then the dose is fine.

    Some people do take as much as tablespoon a day while some would find 3 tsp as high dose. The best way to consume turmeric is to mix its powder in oats along with identical quantity of black pepper powder, boil the mixture in water for a few minutes and consume it in the morning.

    The ideal dosage is three tablespoon full of oats, one third teaspoon of turmeric powder and one third teaspoon of black pepper powder. Oats acts as a vehicle to deliver turmeric powder and pepper powder, apart from being a rich source of fibre.

    This has been tested and proven per cent and I am fully convinced and satisfied with the wonderful results. Hi, Kumar, I have been ingesting turmeric in powder capsules for one year, for my join pain in my knee, with wonderful results-no pain at all, plus other side benefits.

    But one week ago, my pain returned as bad as before taking the turmeric. Do you think its effect runs out with time?

    I mean, is it possible that after many months of use my body is not absorbing it any longer? I suspended the use, and plan to do so for a month, and then restart using it. I would like your opinion. Thank you in advance. I live in South Florida and grow Turmeric in my back yard. I have been distilling my turmeric and making Curcumin essential oil. I have been taking this stuff with a long eye dropper down the back of my throat and then chasing it with some MCT oil and a couple Bioperine tablets.

    Does anybody know how much of this oil I can take in a day? Around 1 ml of curcumin essential oil is fine. You can take it with meals to avoid taking oil and bioperine tablets.

    You do not actually need anything to absorb curcumin if you are using whole turmeric. Bharat B Aggarwal who is pioneer in turmeric and curcumin research if you take raw turmeric, you need not take any other thing at all. How great is that! Fresh turmeric contains oil so you dont need anything to absorb it.

    However including it in meals or cooking it definitely increases absorption. Fresh turmeric, thats the roots, has essential oils and other nutrients that aid in absorption of curcumin, active ingredient of turmeric. But there has been no research that comments on curcumin absorption in the body after taking fresh turmeric root.

    Therefore when it comes to turmeric powder, its best to use black pepper and oil for absorption. But other than that it sounds perfect. Just my opinion though. This is great to hear because I just started using Turmeric, black pepper and coconut oil for the same reason. Can you tell me how long you used your mixture for before you started to see the results?

    I also have pituitary tumour and just been reading these comments. Any more comments on how long it took before seeing any results. It is yet another example of the powerful health benefits of turmeric as can be seen on all the other NutritionFacts videos http: Should we be focusing on getting small amounts of turmeric each day combined with other spices, vegetables and whole starches such as legumes combined with a source of fat from whole foods such as ground flaxseed or small amounts of walnuts rather than focusing on how much of the active ingredient of turmeric we should be taking in capsule form each day?

    Is this not what traditional Indians or Okinawa Japanese did through out their lives, who had very low rates of cancer compared to Western countries? I am a cancer patient and I am interested in boosting my immunity. What is your opinion on the vitamin C drip as a treatment for cancer? There is a video series here on NutritionFacts. Hi Doc, I have stage 4 carcinoid cancer. It is supposed to be a chronic disease but, I still have hope. The only thing that has shrunk my tumors so far is everolimus…and not much.

    There is research that supports the use of Maitake mushrooms. Also look at Inostiol and IP6. Look at research in China and also research using http: In Germany they use mistletoe to shrink tumors. Some clinics in the US may offer this treatment. It may be intervenous. Research also supports the use of tumeric. It is clear that eating lots of vegetables is better for you no matter what your diet.

    I think the whole butter argument is lopsided. In fact there is evidence all around that as the use of butter fat has gone down low fat, no fat, trans fat , the incidence of heart failure has way gone up. The brain and lungs are both composed largely of saturated fats. Can what we are really be bad for us? Our bodies are also made up of a lot of water. Yet we know that drinking too much water can kill us. Or think of this: And yes, eating animals is bad for those animals.

    Biology is a lot more complicated than your question implies. Your earlier arguments are equally flawed. If you are interested in the science, there is plenty of it to be found here on NutritionFacts. I would invite you to spend some time enjoying the informative and entertaining videos on this site.

    I read years ago that ground dry turmeric root is not that bio available. I was told to boil it in water for 10 minutes, or saute in oil to make it more bio available. Does anyone know one way or the other? Thank you for this great article!

    Got a question for you: Does ginger have the same effect as pepper on the absorption process of curcumin in the body? Thanks for this awesome article!! Does ginger effects the curcumin intake as well??? I am curious, why would the liver be trying to get rid of tumeric if it is supposedly good for us? I have a suspicion tha the whole food has everything it needs to make the various substances more bio available.

    One case in point is raw broccoli. It has an enzyme that makes a great substance bio available but cooked or powdered has inactivated enzyme and one does not get the benefits from that substance I think it is NAD or something. I have a suspicion that the whole food has everything it needs to make the various substances more bio available. Hello, I recently spoke with someone who was dealing with some inflammatory reactions and lots of allergies.. I encouraged her to search into an anti inflammatory diet and spoke about the benefits of including turmeric and turmeric paste.

    However, she is allergic to black pepper.. Your comment about Ghee being in some way responsible for heart disease has little if any scientific basis. Saturated fats such as those in ghee are heart protective as shown in hundreds of articles speaking out against the food industries huge promotion of low fat milk and other products.

    Many vital ingredients need good saturated fat for transport in our systems let alone the protective aspect of saturated fats. It is the simple carbohydrates that are the main culprits as well as Poly unsaturated oils invluding the huge hype about omega 3 which is oxidized rapidly in our bodies leaving toxic residues.

    The cutting edge of cell chemistry has shown for nearly 40 years that it is the property of the 4th phase of water that creates the barrier between cells like tiny jello blocks not membranes with all the constant need for inventing newer ion channels and simply not addressing the enormous energy needs if cells did in fact have anything like the transport ideas of membrane pumps.

    You may want to check your facts about fat causing heart disease. Fat, especially sources like ghee, are what lower the small sharp ldl cholesteral that gets stuck in the inflamatian of the heart not caused by cholesteral and aggravates heart disease.

    There is new science out there. Maybe go read it. If you are interested in science, you are in the right place! There are lots of new myths about saturated fat, but not new science.

    Check out these videos: DID their traditional knowledge fail them on butter? However, people in India are also known to use vegetable ghee, which is pretty much like our Crisco here. Plus people in India are largely vegetarian and eat a lot of grain and they probably go around inflamed as often as not. I have been making golden milk with the purathrive curcuma extract: I am just so exited about this product.

    Good luck to all ;. I took it for 4 days and went jaundice and everything else that goes with liver failure. I was just st recovering from that when I had a heart attack leading me to triple bypass. My cardiologist suggested Tumeric. I read if taken with a fat it by passes the liver. I was think if I took fish oil or Vitamin E this might help me recover and help with tumeric.

    Hi Cherie, You have had a really rough time! We learned a lot about herbals and botanicals in my Integrative Medicine fellowship. Our professor for most of this portion is a wonderful, classically trained physician who had been and herbalist prior to going to med school, Dr.

    Tieraona Low Dog, MD. In the herbal world there have been lots and lots of published studies on the benefits of Milk Thistle to support the liver as it heals.

    You might want to start using that as the liver has so much to do with all our functions that having that working less than optimally will slow your recovery of your other problems. Turmeric is great for inflammation but so is ginger. You can get them in the powdered form but they are also roots that you can get from health food stores if you have one around. I like to put a few slices into my morning smoothie and get them incorporated that way.

    The great thing about the ginger is it will also settle your stomach and deal with any nausea you may have. Adding a little black pepper will enhance the absorption of the turmeric into your blood stream.

    I encourage you to look for books and websites by Dr. Low Dog and you can learn more about some alternative remedies. I hope this is helpful. That isanother reason why it is seldom used on its own in oriental countries. You can leave replies to my email. I was on the Turmeric 3D site which referred to the X boost in turmeric effectiveness when coupled with some black pepper and clicked on the link to this page only because I wanted to get hold of citations.

    Great article but quite wrong about ghee. Ghee is not just butter fat there are multiple aspects to it — cow breed, cow feed, probiotics, non pasteurized, gold salts. Could I add milk instead of water? The active compound from the black pepper, piperine, is not contained in cayenne, so that is not a substitute for this particular reason. Black pepper and white pepper are both made from the Piper nigrum plant. This has slightly different values, but again shows similarity between black and white pepper and the active compound piperine- http: Also see here- http: Have Been taking Tumeric with black pepper for over 6 month for a broken, healing leg.

    The pain and swelling disappeared over night. Said it coul probably take close to a year for complete healing, however after six month I started to walk again and there was no pain!

    It will help me to make sure that I am getting the most anti-inflammatory benefits from the turmeric I cook with. Coconut oil contains 11 times as much saturated fat per volume as canola oil and it is probably not a good idea to do this.

    If you are going to do this, please do not encourage other people to do so becaues diets high in saturated fat strongly correlate to heart diseaes and diabetes.

    I take curcumin with piperine in the morning and add cocanut milk to my golden curry chicken at night delicious!!! We ise a black pepper extract Pepperine to help absorbability. Some manufacturers such as NOW have curcumin treated for absorbability. Do note the Real Biggy is the preponderance of plant based diet in India vs. They should lead the forefront. I am currently have chemo and wanting to the best way to take Tumeric, my Naturopath can get me capsules or tumeric liquid what is the best to take these supplements.

    Since turmeric is in same family as ginger, I wonder if the same holds true for using this herb medicinally. Can I get the best way to use turmeric please. I want to know what is a good amount to take each day and in how many doses per day. Also the amount of black pepper or whatever else I should take with the turmeric. And should I just add water to it and drink it raw? Or is there a more effective way to ingest.

    Please, as much specific advise as possibly so I can get the most out of this. What is the ideal amount of Black Pepper to add to Turmeric to get the maximum benefit?

    I had heard that black pepper can shut down the liver detox pathways, thus allowing for toxins to be absorbed. Liposomal Turmeric is a great way to enhance bio-availability of turmeric. What is the ratio of black pepper to turmeric for enhancement? We are making a product that stews these and other spices for arthritis, and internal organ function. Yellow turmeric has so many nutritional value, freshness for daily healthy lifestyle, purity and safety measurement.

    For those interested in boosting the bioavailability of curcumin with piperine, it should be noted that piperine works on a myriad of substances — not just curcumin. Piperine is a common ingredient in many dietary supplements, particularly those that were designed for weight loss. It inhibits a process within the liver called glucuronidation, which is a process in which a glucuronide molecule is attached to various drugs, supplements, and even some nutrients to flush them out of the body.

    If you choose to take a piperine supplement, it is very important to talk to your doctor or pharmacist beforehand. Does heating increase or decrease bioavailability? I read boiling for 10mins increases solubility by 12 fold but does that equate to increased bioavailability? Michael …In reference to your videos regarding anti arthritis formula and its synergistic effects when combined together, I am wondering if I mix turmeric, pepper, ginger, rosemary, and cloves and fusion it like a tea…do I have a better effect than each alone.

    Could you tell me how much pepper would be idea for say, a teaspoon or a tablespoon of turmeric? I would like to mix the two to fill my own capsules.

    Hi Sandra, according to Dr G in this blog post http: Please people, please stick to the subject at hand. A lot of you guys are on the wrong part of the Blog with your questions. May I suggest we utilize the actual food vs the supplements as our typical intake.

    Alan Kadish moderator for Dr. Sounds like to boost bioavailability we should pepper in some pepper and consume turmeric with fat. Nano technology is so cool! I did find a few scientific articles that used nano-curcumin in various ways none directly in healthy people, tho. It seems very promising. That said, I think Dr. Greger would agree with me that nothing replaces going straight to whole food, i. If you do want to supplement instead, the nano curcumin seems like a good option.

    My daughter is taking it as reinforcement for possible therapy in the event she might have cervical cancer. Still waiting for biopsy results, but I read nano curcumin will really be helpful in the event of chemo or radiation therapy. I was wondering, can one use capsaicin from red pepper instead of piperine to boost the levels of Curcumin?

    Hi Evert, my understanding of the absorption properties that increase the blood levels of curcumin is from piperine found in black pepper. I have not seen any studies citing use of red pepper for this. It is interesting that most mixtures of curry contain black pepper along with turmeric which increases the absorption of this mixture in their diet. Turmeric that is not absorbed is not wasted though as it works as a potent anti-inflammatory agent in the gut.

    Gregor and his videos. These sort of statements create a lot of confusion in the consumer world. Piperine boosts bioavailability of curcumin in part by inhibiting these enzymes. There are numerous studies that show piperine also increases the bioavailability of numerous pharmaceutical drugs by this same pathway. Therefore I believe that extreme caution should be exercised when taking supplements containing piperine while also taking pharmaceuticals.

    Also, these enzymes inhibited by piperine are also responsible for helping the body to detoxify many toxins. Piperine inhibits human CYP3A4 and P-glycoprotein enzymes which are involved in the metabolism and transport of xenobiotics and metabolites.

    This way piperine boost the bioavailability of curcumin. Curcumin is the main active ingredient in turmeric. It has powerful anti-inflammatory effects and is a very strong antioxidant.

    I just heard the turmeric needs to simmer or boil for 10 minutes to get the benefits. Cooked turmeric and raw turmeric both have separate benefits. Raw is good for the curcumin and anti-inflammatory effects attributed to not only curcumin, but many antioxidants within the plant.

    Concerning that closing remark about ghee may include an assumption that might not be backed by research: Some other research obviously support these findings: Things are obviously not that simple.

    I would like to see some comments from Michael Greger. According to the University of Maryland , you can take up to 1. Although this does not state how much curcumin is in this amount of root, the site goes on to recommend to mg of curcumin powder, 3 times per day. So we could assume that this amount of root contains mg curcumin, which would indicate about 0.

    Although, this is only an assumption. It is best to go by the stated does of 1. No offence intended but your comment assumes the availability of a store, the named product and the financial means to purchase pre-made supplements if it is in the country where the person who asked the question lives. Please do not respond with the option to order online for the same reasons. I understand you meant well.

    It is not always as easy as running to a store for the majority of the citizens of our planet. With peace and light! What about fat from whole foods? I do not like to consume a lot of oil. I usually take turmeric with my morning smoothie which contains at least 2 tbsp of ground flax and a tbsp of chia and sometimes also hemp… will this suffice? Going off on a small tangent, is anyone familiar with dosing pets with turmeric paste?

    Is the addition of black pepper as beneficial for maximized absorption in dogs as it is in humans? I am considering supplementing with a turmeric-and piperine formula, but I am afraid that the liver enzyme-inhibiting effect could be potentially hazardous since I am currently supplementing daily with safranal. Thanks for your great question. Greger recommends using real Turmeric and not a a supplement.

    You might like this video for more explanation: Most spices are around 7 g per tablespoon, so this would mean TBS. Does anyone have any idea if the hydrophobic elements of cinnamon would have the same kind of effect as piperine in increasing the bioavailability of curcumin and other nutrients?

    I was not able to find any scientific validation of cinnamon having the same effect of inhibiting glucuronidation such as that of the pepper component, piperine. Should it be added after a meal has been cooked, rather than at the beginning or during? You can cook with turmeric, or add it in at the end. This video explains this further — https: I looked into how to increase the absorption rate of curcumin and found out that the black pepper industry was involved in the the said study and that no other study was able to duplicate the results.

    Does anyone know for a fact whether you can substitute white pepper for black pepper to combine with turmeric for bioavailability?

    Darcy, Yes, white pepper has about the same amount of piperine the bioactive component as black pepper; they are from the same plant, just processed differently. See the following link for more information on the piperine component in various peppers. I am reactive to black pepper but know I need the piperine for turmeric absorption!

    I place a large piece of cheese cloth on the cutting board. Grate all of ginger into the middle of the cloth. Grate all the turmeric as well.. Put 10 peppercorns on to the pile of grated roots. Tie the cheesecloth closed. Ideally, nothing should be able to get outside the pouch. Place tied pouch into pot with about 8 cups roiling water distilled or R. Remove from heat and let cool for 10 minutes. Remove the pouch and squeeze liquid back in to pot.

    Add local honey and fresh lemon to taste. I strain if anything got out of pouch I distribute into jars for the week. The Real Coconut Oil Miracle: Impressed with the information on turmeric and black pepper, but how best to take it? Do I just buy turmeric root, grate it and add a pinch of black pepper or do I buy a powder with pepper already added? If buying powder, what brand is best? There has not been any studies on specific brands of turmeric. If you are interested in Turmeric, Dr.

    Greger has a lot of other videos and information you might like: The publication of many manuscripts regarding the use of curcumin in biological studies since the late s. Since that time, curcumin has been reported to have activity for the following indications: In many scientific and medicinal circles, these reported effects of curcumin have marked it as a source of future breakthrough therapeutics for complex diseases that are thought to require potent but nonselective therapeutics.

    It is important, therefore, that any manuscript or research proposal that is based on the bioactivity experimentally tested or computationally predicted of curcumin or its analogues addresses additional characteristics of this natural product: The vast number of manuscripts published on the biological activity of curcumin makes it impossible for researchers to keep up with the state-of-the-art in the field.

    The reactivity against a number of human enzymes that are linked to compound toxicity, reactivity of each of these classes has important implications for potential toxic side effects specific enzyme toxicity, compound has recently been shown to be an active iron chelator in vivo, inducing a state of overt iron deficiency in mice fed diets poor in iron.

    It is possible that long-term curcumin supplementation and a Western-type diet may aggravate iron deficiency. In studies of therapeutic utility, has been reported as cytotoxic against a number of important cancer cell lines. What is infrequently noted is that it also shows cytotoxicity against normal human lymphocytes. Most researchers currently consider this compound as a dietary supplement, and the FDA does not support claims regarding its therapeutic utility. For it to achieve a level of documented therapeutic utility in the United States, researchers will need to show that it is safe and effective for its intended use.

    Curcumin, when tested in an experimental gastrointestinal model , is almost zero. Fresh whole turmeric is better because it has turmeric oil in it. Turmeric as a whole is better than curcumin because turmeric oil improves bioavailability of curcumin and has medicinal value. Many efforts that are currently being made to improve the bioavailability of curcumin; noting that brain tests for concentrations of curcumin remains low.

    Many have reported that curcumin possesses a relatively low toxicity profile; when curcumin applied at high doses, which is not uncommon practice in many in vivo and clinical studies, may present certain dangers that have not been addressed sufficiently.

    Clinical studies have shown that high doses of curcumin is well tolerated in man. Formulations of curcumin with piperine, soluable fibers of fenugreek, liposomes, micelles, nanoparticles, cyclodextrin and turmerone have shown enhanced bioavailability to some extent, each one having its own limitations. At this time there is not enough scientific information to determine an appropriate range of doses for black pepper and white pepper. Keep in mind that natural products are not always necessarily safe and dosages can be important.

    Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Black pepper and white pepper are safe when used with food and might be safe for most people when used in medicinal amounts. Pepper might have a burning aftertaste. Taking large amounts of black and white pepper by mouth, which can accidentally get into the lungs, has been reported to cause death.

    This is especially true in children. Medical experts believe that black pepper extract alters the pathways in the liver and intestines. While this trick allows for greater absorption of turmeric because certain metabolic enzymes are bypassed , it also adversely affects the way that some other drugs and supplements are metabolized.

    Micelles and liposomes are vesicles in which nutrients can be trapped and administered more efficiently; these vesicles are not similar to each other. Liposomes are nutrient carriers and can be considered to be superior for delivery as they directly target bodily cells. Additionally, liposomes are capable of carrying much higher doses of the intended nutrients than a micelle due to their composition.

    Micelles will enhance the uptake of the nutrient, they do not have the same targeted power of a liposome. Ghee, the butter Indians used for centuries in combination with turmeric and pepper and other ayurvedic herbs to enhance bioavailability, keeps puzzling me.

    In this study, ghee made from milk , seems to have very positive effects. Animal studies have demonstrated many beneficial effects of ghee, including dose-dependent decreases in serum total cholesterol, low density lipoprotein LDL , very low density lipoprotein VLDL , and triglycerides; decreased serum cholesterol, triglycerides, phospholipids, and cholesterol esters in psoriasis patients. A study on a rural population in India revealed a significantly lower prevalence of coronary heart disease in men who consumed higher amounts of ghee.

    Non toxic, low dose, fully absorbable. Same price as good quality turmeric supplement but so much more effective …it has 34 studies with various conditions. I was recently diagnosed with low blood iron levels near the bottom of the acceptable range and ferritin levels way below the bottom of the range , and am now pondering whether or not to continue taking my daily dose of turmeric quarter teaspoon and black pepper rather more as I like the kick it gives my morning porridge. Would you recommend using fermented Turmeric to boost bioavailability?

    Any dangers associated with that? Your email address will not be published. Save my name, email, and website in this browser for the next time I comment. By subscribing, you will automatically receive the latest videos emailed to you or downloaded to your computer or portable device. Select the subscription method below that best fits your lifestyle. Copy the address found in the box above and paste into your favorite podcast application or news reader.

    Subscribe to Videos Discuss. A clinical review of different formulations of Vasa Adhatoda vasica on Tamaka Shwasa asthma. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.

    Mol Nutr Food Res. A new paradigm and therapeutic opportunity for the treatment of osteoarthritis: Curcumin for osteoarthritis management. Biochemical basis of enhanced drug bioavailability by piperine: Evidence that piperine is a potent inhibitor of drug metabolism.

    Dietary turmeric potentially reduces the risk of cancer. Biotransformation of curcumin through reduction and glucuronidation in mice. Cholesterol oxides in Indian ghee: Terms You may republish this material online or in print under our Creative Commons licence. You may not use our material for commercial purposes.

    Doctor's Note Why would we care about boosting curcumin levels? Leave a Comment Comment Etiquette. Comment Etiquette On NutritionFacts. To do this we need your help, so here are some basic guidelines to get you started. The Short List To help maintain and foster a welcoming atmosphere in our comments, please refrain from rude comments, name-calling, and responding to posts that break the rules see our full Community Guidelines for more details.

    Are you talking about turmeric, and where did you find this information, please? The milk in the tea comes to the rescue here. Curcumin is soluble in the oil of the milk! Does anybody know how much black pepper to combine with a teaspoon of turmeric? Does the cur cumin need to be combined with the black pepper or oil before consuming it? A significant percentage of the heart disease in Indians is genetic not dietary! Link to the report about the study finding a harmful effect of low cholesterol http: Yes to curcumin and coco ut oil.

    Reducing the size ofmy breast lump. Are there areas of India that are not exposed to Western foods? To be short, see this article for example regarding the harmfulness of PUFAs: Does a little oil help our bodies absorb curcumin? From the World Health Organization: Eat a cup a kale if you want Beta Lycopene, Lutein or Zeaxanthin! Many Thanks for your life changing info. So, to summarize based on the article: Science really has improved upon this: Just make sure you take the right kind methylcobalamin.

    Great video truly, Dr. Greger you are an inspiration to me. I do not have access to the article cited but the first two articles on ghee I found on pubmed conclude that ghee does not increase risk factors for heart disease: Fat helps with absorption.

    Could we please have a straight answer on the safe daily dosage of turmeric powder? Just some ideas for you. Could someone discuss what they know about this: Great info once again Dr G. Certainly some lively discussions in this thread. Does this mean you should avoid putting pepper on fish to avoid vitamin A issues? As always this is great, Dr. Does anyone know how much raw turmeric root would be equivalent to mg curcumin extract?

    Hello i am Vivian, all thanks to Dr. For anyone wondering, the study used the following amounts — 2 g curcumin per human supplement form. Erich, I was not able to find any scientific validation of cinnamon having the same effect of inhibiting glucuronidation such as that of the pepper component, piperine.

    Yes, it ill do. Yared, Nutritionist Volunteer Moderator. I understand turmeric powder is best but if that is off table what is 2nd best way to take it?

    Why Pepper Boosts Turmeric Blood Levels

    Heat is said to increase the solubility of curcumin (the primary active constituent in turmeric) by 12 times, which may also increase its bioavailability in the body. Turmeric is poorly absorbed in the body. Here are some simple tips to improve its absorption in the body. “The CW8 formulation showed a fold increase in relative bioavailability compared with unformulated standard curcumin,”​ commented.

    94 comments on “Curcumin Will Waste Your Time”



    Comments

    nefertity

    Heat is said to increase the solubility of curcumin (the primary active constituent in turmeric) by 12 times, which may also increase its bioavailability in the body.

    HENSOLO

    Turmeric is poorly absorbed in the body. Here are some simple tips to improve its absorption in the body.

    wokens

    “The CW8 formulation showed a fold increase in relative bioavailability compared with unformulated standard curcumin,”​ commented.

    darkmagnum10

    There are ways to improve the bioavailability and absorption in the body. Combining black pepper with turmeric is one way to help the turmeric.

    Gorax

    We don't see a large increase because our liver is actively trying to get rid of The same amount of curcumin consumed, but the bioavailability.

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