Binding with TRPV1 Receptors

for CBD ALS Nordle



  • for CBD ALS Nordle
  • Study Reviews Evidence Supporting Use of Cannabinoids to Treat ALS
  • Comprehensive research on amyotrophic lateral sclerosis and The CBD cannabinoid is proven to be an exceptional seizure-controlling. CBD Oil for ALS (Lou Gehrig's Disease): A "Lock and Key" Combination? ALS, otherwise known as amyotrophic lateral sclerosis (or more simply as Lou Gehrig’s Disease), is one of those rare neurological conditions with no known cure and for the most part, no known cause. Click Here to receive ALS News via e-mail Indeed, the spinal cord of ALS patients has been shown to present motor We are currently attempting to use this(CBD oil) with my father who most likely has very advanced ALS.

    for CBD ALS Nordle

    It gave me a very happy high. You guys are doing awesome work! I am waiting for the next pack with the Therapy with even lower thc content.

    Thank you so much for your feedback, so glad you liked them! She has non cancerous brain tumors meningiomas located at the base of skull near the connection with spine. It causes her very painful rigidity of neck muscles and head tremors.

    She s been smoking the cbd shark i ve grown for her for about 1 month and let me tell you that results are impressive. She has stopped her anti tremors drugs and antidepressants!

    And her general life quality has improved significantly. Her neurologist is aware of that and agree her on using cannabis….. So I want to thank you all guys for your work. As someone prone to getting a racing heart, dizziness, confusion and paranoia, when smoking traditional strains, I have found out the real pleasure of smoking cannabis thanks to your high cbd strain.

    CBD Nordle is so mellow and relaxing… I can definitely feel the heightened perceptions, the relaxed muscles and the somewhat altered way of thinking typical of THC, but at the same time my mind is able to focus and I feel calm and centered. Thank you so much! Thank you so much for Therapy. I have made my first batch of And we now are saving so much money. When my father was diagnosed with ALS in , he was given years to live with no known cure at hand.

    Did my research on cannabis and ALS and found hope in some clinical trials. Truly a miracle for us to witness. Your genetics are excellent. I just want to thank you for bringing such quality back in to the gene pool. I have your CBD critical in the garden and was blown away by the production, aroma, and efficacy. I have some curing that just oozes with fruity berry aromas and I can alleviate anxiety and muscle aches I regularly surf, snowboard, train martial arts without getting too stoned. I am a true believer in 1: Keep up the good work!!!

    We have therapeutic users with chronic diseases who try medicine with a cannabis butter with ratio 1: Some relatives start to grow in order to get their own cannabis flowers to make the extract. This kind of people also like make a cultivation with their own strains.

    They like going to a cannabis club to get their dispensation without having to go the black market. The favorite flavors are chocolate, strawberry, orange and lemon and they would like to try them in sweeties and ice cream.

    I really congratulated you for the work you are doing. Dream come true … growing without paranoia of justice. And your other CBD seeds are so good, so smooth…makes my day.

    This is the BEST alternative for alcohol-addiction and all the bad habits we have with this alcohol-problem. We have to change the community with that.

    Thank you so much!! Im George from G—-. I grew cbd critical mass mainly for my anxiety and depression. Here i present you my two beautiful plants right before harvest see attached pics. Considering it was my first grow and the lamp was only w, i think these two plants performed really good. After a few days of drying, i tried a few buds in a joint.

    What i have to report is the following:. First of all the effects have nothing to do with effects from high thc strains. The first minutes i felt a mild relaxation and a small stoned feeling in my head, but really really light and pleasant. A slight headache I had dissapeared and this was very nice! After about 40 minutes and towards the end of the joint, the whole relaxed feeling turned into a more active-sativa like buzz.

    That was really interesting, because normally i feel like a zombie because of the antidepressants i take, and this made me go out and do things and be active. My aunt had a few puffs as well, and she said it gave her an active feeling as well.

    But maybe two joints were too much for a start, Maybe i must start with smaller dosage. I sleep better and am able to medicate while doing daily tasks and activities. I really wish I could get my hands in more seeds but due to being from NY I am not able to anymore. Thank you so much, that really means a lot to us. Hope you get your hands on more medicine! I just want to tell you that Uncas has birthday today! For a week I thought that I had to bring him to the doctor that Uncas is allowed to die because he was not eating for more then two days!

    I giving him your tincture. Now he is eating again. And he is running around, jumping to everywhere, this week catching a mouse and I think your oil is a great help!!! So I am very lucky!!! As the huge animal lovers as we are here at CBD Crew, we are so glad to hear this! Helping our furry friends warms our harts. It helps me sleep helps me with my anxiety helps me with my pain and I love it. I also have your CBD therapy which is also very helpful as well as CBD Medi haze which provides great daytime relief of pain and anxiety.

    Thanks once again and keep up the great work! Thank you for the great feedback, glad you found strains that work for you! She was diagnosed a polynephrite which creates harsh pain in her feet when she is laid at night.

    Another problem erased with cannabis: Then she can wake up in the morning without these problems. CBD skunk haze was first which helped me. First I tried z6 and z7 but never manage to get right pheno.. You love and take care of all of them.. And you always want to be fair to give them all same amount of light and all.. And only first 2 or 3 weeks was hard. Like I stayed in bed binge watching series.

    But I think I wanted too much too fast and I was taking down 2 pills a day. And I needed some time to adjust to oil etc. But later it was easy. I started to take down half of pill a day.. I think I was on 2 pills after 2 months or so.. So reality is that it is possible to get down from 27 to 2 in 2 months methadon I was taking was 10mg per tablet.. What an accomplishment, you are truly a brave person. I like to share my experiences with your seeds today. I suffer from nerve pain and sometimes anxiety, specially when i smoke high thc strains.

    So I tried this strains and it is really amazing! It helps me so much with my nerve pain and gives me no anxiety at all. It changed my life for ever;from a young woman traped in her failing body, to a very joyful an mostly pain free life!

    So happy to hear, chronic pain is something nobody should have to suffer trough. CBD Crew has changed my opinion on medicinal cannabis into real medicine for pain management. I have had liver issues from taking strong painkillers. So I had researched into cannabis sativa. It worked good for my depression by allowing me to get outside and live my life. Make new friends who also enjoyed the herb. However I found it too much when I had a haze strain.

    Or a strong hybrid. Time would slow down too much and I got high anxiety causing me to forget how to breathe. So I had researched the differences and came across cbd. The smell of fruit salad and candy apples were to die for. The high was like being at a concert after a few shots of tequila. Just right enough to notice an enhanced state of mind. Pain just melts away the body aches, arthritis and you wake up after the journey feeling brand new.

    Try CBD Nordle for pain relief and being able to function in everyday life without raising suspicions. I hope to visit you one day once I am well. So glad to hear things are going the right way!

    We hope to see you one day as well, keep up the good work MDL. I worked with you CBD Skunk haze for over a year now and am looking for a new strain. I think I told you guys over facebook this, but a CBD responsive cancer that had matastacized was literally destroyed within the first round of Chemo by vaporizing 1 gram per day of CBD Skunk haze. The 2 years i was medicated on my 1: I once had the pleasure of growing a crop of CBD critical mass by you guys. It was perfect for me, large yields and zero anxiety, it just relaxed me without making my head spin.

    Now im going to start a new grow…. Very good effect on inflammation and against pain as well. No harsh psychoactive effects even at very high dosage of drops daily, only sleepiness and mild fatigue. I can recommend it for autoimmunitary diseases and inflammatory conditions currently treated with antibiotics.

    I live in Central Europe, Czech Republic — presently Nordle plants only start to flower here, but before the mid-October they should be ready for harvest. You can read more about it in the book: That is great to hear and thank for spreading much needed knowledge in you book! I get severe anxiety with high thc marijuana so, I decided to try some high cbd marijuana in hopes that I could smoke again. Maybe some flavorless weak pot that could pass for hemp.

    It has every bit as much resin as any high thc pot in existence. And the smells and flavors are extremely rich and complex. From woody honey musk to citrussy lemon berry. This is high grade stuff. Its impossible to ignore. I am now able to smoke again without horrid anxiety.

    Its nice and mellow but powerful. In a world where it seems every business is just out to take your money and screw you,its great to see something like this that can help so many people. I get emotional thinking about it. You have a lifelong customer. That is so great to hear, thank you so much for your story and the kind words, we truly appreciate it!

    From a mail we got from a dispensary in Pakistan that we are very happy to hear form and exited to follow in the future!

    Her full remission response with chemo and cannabis 1: And the initial response was astronomical bringing her white blood cells from about to in week one and over in week two and finally to normal by week three.

    Of course with decrease in cancer cells. Other than simply giving you guys feedback, I want to thank you for your work, taking a stand in this industry and helping those suffering. Thank you for sharing and yes, we need to get the whole plant legalized, hemp is not the answer for medical use. I have been growing cannabis outdoors in the UK for over 15 years.

    I plant many unknown strains each year. I also plant some select varieties to see how they perform in this climate. When cultivating I let nature take its course for the most part and interfere very little in the process.

    I germinate around the end of March and nurture the young plants for around two to three months. I then plant them out in the wild.

    From June to the eventual harvest in late September I water around every two to three weeks and only use fertilizer organic up until the end of August. In my harvest the CBD Nordle produced the largest yield and the healthiest plant.

    From this one plant I harvested around 80 grams. I have tried both the cold and hot method and prefer the hot method. First baking the chopped material below the combustion temperature around Celsius , then simmering in the vodka in a water bath. I use two pipettes as a standard dose. This tincture is wonderful for insomnia and mild pain relief I suffer from headaches. It takes around 30 minutes to take effect and its psychoactive effects are noticeable yet mild and last for around two hours.

    I used a further 25 grams to make cannabis infused coconut oil for baking. This I used in a rich Christmas fruitcake, which was enjoyed by the whole family.

    I smoke and vaporize the hash and the bud, which provides me with inspiration in creative and academic activities whilst also easing any mild depression and anxiety I sometimes experience. I love this strain and the fact that it grows successfully outdoors. Many people in my cannabis social group prefer the less intense sensations of outdoor, organically grown cannabis.

    The latter of these studies, however, analyzed cannabis and alcohol in high-risk subjects. Thus, schizophrenia patients should probably not use cannabis because a psychotic episode can be induced in someone with a preexisting disorder and, indeed, increased hospitalization rates and symptom exacerbation have been demonstrated.

    Authors of additional studies have found a possible connection between lower levels of the endocannabinoid 2-AG and schizophrenia progression, as well as impaired endocannabinoid signaling associated with acute psychotic episodes. Giuffrida pointed to the different pharmacologic profiles of THC and anandamide. But when you elevate anandamide, the elevation does not happen all over the brain but happens in specific brain areas. Giuffrida reiterated that cannabis can sometimes help certain schizophrenia symptoms, which might explain why some patients might self-medicate with the herb.

    But, on the other side, there is some work showing that the cannabinoids have a beneficial effect on the negative symptoms of schizophrenia, so they make people interact more with each other. But what happens with marijuana, especially if you are a psychotic individual, the more you use cannabis, the worse your symptoms become over time.

    So it can be helpful in the beginning, but definitely not in the long run. This Phase II, double-blind, four-week trial compared CBD treatment with the antipsychotic drug amisulpride and found that CBD improved symptoms as well as the pharmaceutical — and that it produced fewer negative side effects. Additionally, he said some animal and human studies show that CBD boosts levels of the endocannabinoid anandamide, and elevated anandamide seems to have a beneficial effect on schizophrenia.

    Based on the available evidence — which includes epidemiological studies, surveys, brain morphology analyses, and a few human studies — most experts accept that cannabis intake could have negative impact on individuals who have schizophrenia and that those vulnerable to developing schizophrenia can have psychotic episodes if they ingest high doses of cannabis. It is not the cause of schizophrenia. Cannabis may cause schizophrenia-like brain changes. Accessed March 18, Drowned in a stream of prescriptions.

    Introduction to the endocannabinoid system. Accessed April 2, Reviewed June 17, National Institute of Mental Health website. Drugs and Human Performance Fact Sheets. National Highway Traffic Safety Administration website. Cannabis abuse and brain morphology in schizophrenia: Eur Arch Psychiatry Clin Neurosci. Behavioral, cognitive and psychophysiological effects of cannabinoids: Revista Brasilerira de Psiquiatria. Confirmation that the AKT1 rs genotype influences the risk of psychosis in cannabis users.

    Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. In every human there are complex biological systems working to keep physiological functions in order. When these biochemical systems are functioning optimally, they maintain optimal mood, help maintain appropriate levels of immunity, proper digestion, regular sleep, brain function, etc.

    The housekeeping properties of these systems have an important role in modulating health and disease. One of these systems is the endocannabinoid system ECS. The ECS maintains normal cerebral and physiological function. Human clinical trials and animal studies show that stimulating this biochemical system can have both highly beneficial health effects and few negative side effects.

    Cannabis Cannabis sativa, Cannabaceae; common name marijuana, among others has been used for centuries to treat neurological and neurodegenerative disorders such as epilepsy or spastic disorders.

    The medieval Arab writer Ibn al-Badri documented the use of hashish or a cannabis concentrate to cure a neurodegenerative disorder probably epilepsy afflicting the son of the chamberlain of the Caliphate Council in Baghdad.

    Tetrahydrocannabinol THC from the cannabis plant stimulates CB2 receptors, which decreases neuroinflammation by inhibiting the movement, growth, and activity of immune cells.

    Basically, the stimulation of the ECS by constituents from the cannabis plant results in decreasing the migration and activation of the immune cells that maintain the environment of neurodegenerative disorders, thereby disrupting the signals that sustain inflammation and cell death. Another important aspect of neurodegenerative disorders is the irreversible death of neurons leading to progressive dysfunction.

    Excessive glutamate receptor activity is known to cause neuronal cell death by damaging cells and creating reactive oxygen species ROS. The CB1 receptors found in the brain have a direct effect on neurons by limiting glutamate release when stimulated at the presynaptic nerve terminals.

    Glutamate is a key neurotransmitter, derived from glutamic acid, an amino acid. Stimulation of the ECS also has pro-survival effects on brain cells. At the present time, the evidence of the ECS as an appropriate target to treat neurodegenerative and other diseases does not come solely from the limited approved studies on marijuana from the U. The information comes from a wealth of new information about stimulating this biological system and the mechanisms explaining the central role of this system in health.

    The ECS is inherent to proper human functioning; in fact, every physiological system that has ever been studied is positively modulated by it.

    Since the isolation and structure elucidation of the main ingredient found in cannabis THC in the s, several research groups have explored THC and other cannabinoids for therapeutic effects e.

    For example, experimentally derived combinations of THC and CBD have been documented to synergistically inhibit cancer cell growth in Petri dish experiments on human grade IV glioma cells by increasing activity in a specific molecular pathway when co-applied. In mammals, the ECS is modulated during disease or injury; for example, CB2 receptor density is increased during inflammation or bone injury.

    There is evidence supporting a modulation of this biochemical system in a number of disease models. In addition to anecdotal reports and more than 30, basic scientific studies with cannabinoids, there are also over published clinical studies that have looked at the effect of a variety of cannabis-based medicines including inhaled whole-plant material, oral THC capsules, and cannabis extracts on the treatment of a wide range of disorders.

    The therapeutic rationale for combining THC and CBD, and other cannabis plant components in fixed ratios, can result in a decrease in unwanted side effects and an enhancement of therapeutic benefits.

    Jahan Marcu, PhD, is currently the senior scientist at Americans for Safe Access and chief auditor for Patient Focused Certification, an oversight program that audits cannabis operations. Marcu is the director of research and development at Green Standard Diagnostics, Inc. He is also on the board of directors of the International Association for Cannabinoid Medicines. He received his PhD for significant contributions to the study of the structure and function of the cannabinoid receptors.

    He is also an author of the American Herbal Pharmacopoeia's cannabis monograph. Pacher P, Kunos G. Modulating the endocannabinoid system in human health and disease — successes and failures. The endocannabinoid system as an emerging target of pharmacotherapy.

    Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Defective adult neurogenesis in CB1 cannabinoid receptor knockout mice. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Deletion of CB2 cannabinoid receptor induces schizophrenia-related behaviors in mice. The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety.

    Critical role of the endogenous cannabinoid system in mouse pup suckling and growth. Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: Janero DR, Makriyannis A. Expert Opin Emerg Drugs. The pharmacohistory of Cannabis sativa. Cannabinoids as Therapeutic Agents. Karler R, Turkanis SA. The cannabinoids as potential antiepileptics.

    The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis. Cannabinoid system and neuroinflammation: Marijuana, endocannabinoids, and epilepsy: Cannabis in the Management and Treatment of Seizures and Epilepsy: American Herbal Pharmacopoeia; Gloss D, Vickrey B.

    Cochrane Database Syst Rev. An efficient new cannabinoid antiemetic in pediatric oncology. Chemical constituents of marijuana: The complex mixture of natural cannabinoids. Constituents of Cannabis sativa, XXV. Isolation of two new dihydrostilbenes from a Panamanian variant. Marijuana and the Cannabinoids. Chemistry and analysis of phytocannabinoids and other cannabis constituents.

    Ito K, Ito M. The sedative effect of inhaled terpinolene in mice and its structure-activity relationships. Russo E, Guy GW. A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Cannabis and cannabis extracts: Journal of Cannabis Therapeutics.

    Agonistic properties of cannabidiol at 5-HT1a receptors. Role of cannabinoids in pain management. Springer New York; Cannabis-based medicines in multiple sclerosis — A review of clinical studies. Peripheral cannabinoid receptor, CB2, regulates bone mass. The cannabinoid receptor type 2 as mediator of mesenchymal stromal cell immunosuppressive properties. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. Role of cannabinoids in the regulation of bone remodeling.

    Differential activation of intracellular versus plasmalemmal CB2 cannabinoid receptors. Clinical endocannabinoid deficiency CECD: Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population. The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.

    Rom J Intern Med. Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Hazekamp A, Grotenhermen F. Review on clinical studies with cannabis and cannabinoids Cannabinoids Cannabinoids are a group of carbon—containing terpenophenolic compounds produced uniquely by Cannabis sativa and Cannabis indica species. Antitumor Effects One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.

    Pharmacology, Toxicology, and Therapeutic Potential. The Haworth Press, Br J Pharmacol 2: Inhibition of glioma growth in vivo by selective activation of the CB 2 cannabinoid receptor. Cancer Res 61 Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

    J Clin Invest 1: Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res 64 Nat Rev Cancer 3 Inhibition of tumor angiogenesis by cannabinoids. Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism. Br J Pharmacol 8: Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule Towards the use of cannabinoids as antitumour agents.

    Nat Rev Cancer 12 6: A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther 10 1: Anti-tumoral action of cannabinoids on hepatocellular carcinoma: Cell Death Differ 18 7: Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.

    Cancer Prev Res Phila 4 1: Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. PLoS One 6 9: Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy. Mol Cancer Ther 10 7: Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

    J Mol Med Berl 90 8: Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Deltatetrahydrocannabinol inhibits antitumor immunity by a CB2 receptor-mediated, cytokine-dependent pathway. J Immunol 1: Deltatetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response.

    J Immunol 6: The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest 8: Biochem Soc Trans 33 Pt 4: Cannabis-derived substances in cancer therapy--an emerging anti-inflammatory role for the cannabinoids. Curr Clin Pharmacol 5 4: Update on the endocannabinoid system as an anticancer target. Expert Opin Ther Targets 15 3: Cannabinoids for cancer treatment: Cancer Res 68 2: Endocannabinoids, feeding and suckling--from our perspective.

    Int J Obes Lond 30 Suppl 1:

    Study Reviews Evidence Supporting Use of Cannabinoids to Treat ALS

    Strains can have a CBD to THC ratio of all the way up to and kush: Appropriately named, this strain is popular among those with ALS. Nordle: A newly developed medical strain that is also balanced at around Amyotrophic Lateral Sclerosis (ALS)/Lou Gehrig's disease: Sexxpot Inclusion Body Myositis: Nordle (Indica, THC: %, CBD: %). Das Themenbereich Cannabidiol(CBD) als Medikament wird immer 4 Prozent) und die CBD Nordle (CBD: knapp 9 Prozent, THC knapp 6.




    Strains can have a CBD to THC ratio of all the way up to and kush: Appropriately named, this strain is popular among those with ALS. Nordle: A newly developed medical strain that is also balanced at around


    Amyotrophic Lateral Sclerosis (ALS)/Lou Gehrig's disease: Sexxpot Inclusion Body Myositis: Nordle (Indica, THC: %, CBD: %).


    Das Themenbereich Cannabidiol(CBD) als Medikament wird immer 4 Prozent) und die CBD Nordle (CBD: knapp 9 Prozent, THC knapp 6.


    CBD Crew has produced some of the most stable CBD/THC rich cannabis seeds on the market. The joint CBD Nordle - Feminisierter - CBD Crew. Ab: 41,50 €.


    Medicinale marihuana wordt nu internationaal erkend als natuurlijk medicijn. CBD is uit de schaduw van THC getreden en is de eerste.

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