Cannabis Compound May Help Reduce Symptoms of Psychosis of people who have conditions such as schizophrenia and bipolar disorder. (CBD) could someday be an effective alternative to the antipsychotic drugs in. ) of CBD as an adjunct to antipsychotic treatment in people with schizophrenia. . Fakhoury, M. () Could cannabidiol be used as an alternative to antipsychotics? He is interested in the philosophy of mental illness. A cannabis extract could help treat symptoms of psychosis even The team from King's College London found cannabidiol (CBD), THC is thought to be a significant risk factor for psychosis and other conditions like schizophrenia. multiple hospital sites, to confirm whether CBD can be an alternative.
– for Treatment Schizophrenia? Alternative CBD Psychosis &
Baseline outcome measures were similar between groups. However, they found no impact on negative psychotic symptoms. Overall, these results suggest that CBD has an antipsychotic effect in schizophrenia when delivered as an adjunct treatment. However, this effect appears to be very modest and limited to only positive psychotic symptoms. This study was the first double-blind RCT to be published investigating CBD as an adjunct to existing antipsychotic treatment. It is the largest trial of CBD as an antipsychotic in patients with schizophrenia so far reported.
It also trialled a slightly higher daily dose than other studies 1, mg compared to mg. Retention was excellent with just one withdrawal from each group, which in both cases was due to adverse symptoms. It was an international study, which recruited participants across three countries, which helps with the generalisability of the results.
Overall this a high quality study that offers the best evaluation to date of the antipsychotic effect of CBD in patients. However, further and larger double-blinded trials are required to explore the replicability of these results.
Importantly, the trial included participants who were already being treated with antipsychotic medication. Therefore the beneficial effects for CBD are in addition to those from existing treatment, suggesting that CBD may be a helpful adjunct therapy to current antipsychotic medication.
Evidence collected using a different study design is needed to investigate CBD as a standalone treatment. The primary limitation with the study design was its size. It was a phase two trial of a novel medication and such trials typically include hundreds of participants.
So the study should at most be taken as an indication that CBD may have an antipsychotic effect arguably meriting further research, and not clear evidence that it does. Another concern is about the modest benefit of treatment. Clinician rated improvement and wellness scores showed a minimal to moderate improvement in most cases. Other outcomes were not statistically significant.
Fascinatingly, the human body is perfectly able to adapt to different cannabinoids, or compounds found in the cannabis plant. We are all also having something called an endocannabinoid system ECS. Scientists discovered its existence fairly recently. The ECS, as the name suggests, is our on board system for producing our own cannabinoids. Our bodies manufacture some of the same compounds that are, as far as we know, unique to the cannabis plant and our own ECS.
Yes, you read that right — our body is wired to respond to the chemicals and compounds found in cannabis! It seems that supplying our body with cannabis might be giving it exactly what it wants. It follows that we also have the correct receptors to which these neurotransmitters bind. This is how they deliver their healing benefits to us.
CBD oil for schizophrenia is not yet universal. Doctors commonly prescribe antipsychotics as the primary treatment for schizophrenia. However, they have some serious side effects. For one, they can reduce sensations of pleasure and motivation. Perhaps the most worrisome potential side effects of conventional antipsychotics, however, are movement disorders that can be utterly devastating.
They are sometimes permanent. CBD oil for schizophrenia has demonstrated equal levels of effectiveness in treating Schizophrenia and Tourette Syndrome. Research has linked schizophrenia with elevated levels of a particular neurotransmitter known as Anandamide. This molecule appears in higher concentrations in patients with a higher severity of symptoms.
Fortunately, the neuro transmitter interacts with the same receptor as some cannabinoids. However, the elevated levels of Anandamide do not seem to be connected to causality when it comes to Schizophrenia.
On the contrary, Anandamide is known as an endogenic antipsychotic and stress reliever. This has far-reaching implications. If Anandamide helps a body avoid psychotic episodes, how can we help the body along and provide more of this compound? If CBD oil could help to reduce the episodes of schizophrenia in people who are suffering from a mental health disorder, it could solve a lot of problems at once.
Mental health does not just affect the person with the condition. No, it affects everyone around him or her. Many homeless people are on the streets because of poor mental health. Many of them have schizophrenia, if somehow there is a diagnose for them. If CBD oil could help to lessen these symptoms or make people more responsive to treatment, it may help them to get off the streets. This would create a cleaner, safer communities for everyone.
The CBD molecule does explicitly not activate this Anandamide receptor, so what is its role in this equation? CBD seems to preserve the Anandamide molecules in the mind by somehow lessening their decay and destruction. This allows the existing Anandamide to remain in higher concentration for much longer. Thereby, it bolsters its antipsychotic effect.
Another role of Anandamide in mental health is related to the relatively well researched neurotransmitter Dopamine 2. This includes when they present themselves in the context of disorders such as Schizophrenia. Since, as noted, CBD acts as an Anandamide preservative, deployment of CBD oil as a treatment might be able to help diminish psychotic symptoms.
Scientists have not proven this yet. Scientists must conduct further research. That being said, it seems unlikely that a natural therapy like cannabis — or any sort of medication, for that matter — might be effective in reversing the onset of the condition. However, studies that analyze the effects of marijuana for schizophrenia and psychosis have been going on for years, and now, scientists are starting to turn their attention specifically to CBD as a possible treatment.
We mentioned that psychosis and schizophrenia are mental disorders that represent a total detachment from reality, but what is it that actually causes this to happen? What takes place in the brain that drives an individual to become separated from the real world? In short, scientists are not sure what exactly causes the onset of psychosis or schizophrenia. Regardless of what you may have heard in the past, they are unsure of why some people develop psychotic symptoms over the course of their life, and others do not.
Unlike medical conditions like diabetes or heart disease, no one has been unable to pinpoint an exact physiological condition which accounts for the disorder.
In terms of genetics, for example, it has been proven that schizophrenia tends to run in families, so if you have a family member that has gone through psychotic episodes in the past, you may be more likely to develop the disorder at some point in your life. However, no one single gene has yet been traced to the disease onset.
Likewise, studies have shown that individuals with psychosis undergo changes in the physical structure of the brain.
CBD for Psychosis and Schizophrenia: An Update on New Studies
(1)Department of Neuroscience and Behavior, Faculty of Medicine, University Additionally, CBD prevented human experimental psychosis and was effective and clinical trials in patients with schizophrenia with a remarkable safety profile. Does weed improve schizophrenia symptoms? for integrative care and alternative medicine approaches located in Portland, Oregon. . some research suggests there could be benefits from using CBD to treat psychosis. Perhaps because there's so much stigma associated with mental illness in general, and schizophrenia is notoriously difficult to treat, we'd never.